Literature summary for 3.1.4.35 extracted from

Mochida, H.; Noto, T.; Inoue, H.; Yano, K.; Kikkawa, K.
T-0156, a novel phosphodiesterase type 5 inhibitor, and sildenafil have different pharmacological effects on penile tumescence and electroretinogram in dogs (2004), Eur. J. Pharmacol., 485, 283-288.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-(2-methylpyridin-4-yl)methyl-4-(3,4,5-trimethoxyphenyl)-8-(pyrimidin-2-yl)methoxy-1,2-dihydro-1-oxo-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride	i.e. T-0156, IC50: 0.23 mM, potent and highly selective phosphodiesterase type 5 inhibitor	Canis lupus familiaris
sildenafil	IC50: 3.6 nM	Canis lupus familiaris

Organism

Organism	UniProt	Comment	Textmining
Canis lupus familiaris	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000036	-	IC50: 3.6 nM	Canis lupus familiaris	sildenafil
0.23	-	i.e. T-0156, IC50: 0.23 mM, potent and highly selective phosphodiesterase type 5 inhibitor	Canis lupus familiaris	2-(2-methylpyridin-4-yl)methyl-4-(3,4,5-trimethoxyphenyl)-8-(pyrimidin-2-yl)methoxy-1,2-dihydro-1-oxo-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride

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Release 2023.1 (January 2023)