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Literature summary for 3.1.4.35 extracted from

  • Dolci, S.; Belmonte, A.; Santone, R.; Giorgi, M.; Pellegrini, M.; Carosa, E.; Piccione, E.; Lenzi, A.; Jannini, E.A.
    Subcellular localization and regulation of type-1C and type-5 phosphodiesterases (2006), Biochem. Biophys. Res. Commun., 341, 837-846.
    View publication on PubMed
Search for more literature for 3.1.4.35

Localization

Localization Comment Organism GeneOntology No. Textmining
centrosome
-
 Homo sapiens 5813
-
centrosome PDE5 Homo sapiens 5813
-
cytoplasm PDE5 is localized in discrete cytoplasmic foci Homo sapiens 5737
-
cytoplasm isoform PDE5 is localized in discrete cytoplasmic foci Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PDE5 regulation of cGMP intracellular levels is not involved in the control of progression of smooth muscle cell cycle, but may represent one of the markers of the contractile phenotype ?
-
 ?
additional information Homo sapiens isoform PDE5 regulation of cGMP intracellular levels is not involved in the control of smooth muscle cell cycle progression, but may represent one of the markers of the contractile phenotype ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens
-
 isoform PDE5
-

Source Tissue

Source Tissue Comment Organism Textmining
myometrium
-
 Homo sapiens
-
myometrium myometrial cell, level of isoform PDE5 decreases in all conditions that inhibit proliferation Homo sapiens
-
smooth muscle cell PDE5 protein levels are strongly regulated by the mitotic activity of the smooth muscle cells, they are increased in quiescent, contractile myometrial cultures, and conditions in which proliferation is inhibited Homo sapiens
-
smooth muscle cell isoform PDE5 protein level is strongly regulated by the mitotic activity of cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PDE5 regulation of cGMP intracellular levels is not involved in the control of progression of smooth muscle cell cycle, but may represent one of the markers of the contractile phenotype Homo sapiens ?
-
 ?
additional information isoform PDE5 regulation of cGMP intracellular levels is not involved in the control of smooth muscle cell cycle progression, but may represent one of the markers of the contractile phenotype Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PDE5
-
 Homo sapiens
type-5 phosphodiesterase
-
 Homo sapiens