Literature summary for 3.1.4.35 extracted from

Buhimschi, C.S.; Garfield, R.E.; Weiner, C.P.; Buhimschi, I.A.
The presence and function of phosphodiesterase type 5 in the rat myometrium (2004), Am. J. Obstet. Gynecol., 190, 268-274.

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Application

Application	Comment	Organism
medicine	potential role for the PDE5 inhibitor sildenafil as an adjunct for the treatment of preterm labor	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
sildenafil	pharmacologic inhibition of PDE5 in uterus blunts myometrical contractility during active labor without a significant cardiovascular effect. Potential role for sildenafil as an adjunct for the treatment of preterm labor	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
uterine wall	constitutively present. No change in PDE-5 protein expression throughout pregnancy	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
PDE-5	-	Rattus norvegicus
phosphodiesterase type 5	-	Rattus norvegicus

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Release 2023.1 (January 2023)