Literature summary for 3.1.4.35 extracted from

Yamazaki, M.; Li, N.; Bondarenko, V.A.; Yamazaki, R.K.; Baehr, W.; Yamazaki, A.
Binding of cGMP to GAF domains in amphibian rod photoreceptor cGMP phosphodiesterase (PDE). Identification of GAF domains in PDE alphabeta subunits and distinct domains in the PDE gamma subunit involved in stimulation of cGMP binding to GAF domains (2002), J. Biol. Chem., 277, 40675-40686.

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Activating Compound

Activating Compound	Comment	Organism	Structure
PgammaPDE6	regulatory subunit of PDE6, activation of cGMP binding to GAF domains of PDE6alpha or beta subunit	Lithobates pipiens

Inhibitors

Inhibitors	Comment	Organism	Structure
PgammaPDE6	regulatory subunit of PDE6, inhibition of catalytic activity	Lithobates pipiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
photoreceptor outer segment membrane	peripherally attached under dark conditions	Lithobates pipiens	42622	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
guanosine 3',5'-cyclic phosphate + H2O	Lithobates pipiens	-	guanosine 5'-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Lithobates pipiens	Q8UUY2	-	-
Lithobates pipiens	Q8UUY6	-	-
Lithobates pipiens	Q8UUY7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
photoreceptor	rod outer segment	Lithobates pipiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
guanosine 3',5'-cyclic phosphate + H2O	-	Lithobates pipiens	guanosine 5'-phosphate	-	?

Subunits

Subunits	Comment	Organism
tetramer	alpha,beta,gamma2, PDE6 consists of two homologous catalytic subunits and two identical regulatory subunits	Lithobates pipiens
tetramer	alpha,beta,gamma2, PDE6 consits of two homologous catalytic subunits and two identical regulatory subunits	Lithobates pipiens

Synonyms

Synonyms	Comment	Organism
cGMP phosphodiesterase	-	Lithobates pipiens
PDE6alpha	catalytic alpha subunit	Lithobates pipiens
PDE6beta	catalytic beta subunit	Lithobates pipiens
PDE6gamma	inhibitory gamma subunit	Lithobates pipiens

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Release 2023.1 (January 2023)