Literature summary for 3.1.4.35 extracted from

Sopory, S.; Balaji, S.; Srinivasan, N.; Visweswariah, S.S.
Modeling and mutational analysis of the GAF domain of the cGMP-binding, cGMP-specific phosphodiesterase, PDE5 (2003), FEBS Lett., 539, 161-166.

Search for more literature for 3.1.4.35

Activating Compound

Activating Compound	Comment	Organism	Structure
cGMP	allosteric activation, cGMP binds to F205 in N-terminal GAF-domain of PDE5	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
cloning of cDNA, expression of PDE5A GAF domain in Escherichia coli	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
D299A	mutation in GAF-domain, no change in cGMP binding affinity	Homo sapiens
F205A	mutation in GAF-domain, no cGMP binding	Homo sapiens
F205Q	mutation in GAF-domain, no cGMP binding	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
sildenafil	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
guanosine 3',5'-cyclic phosphate + H2O	Homo sapiens	-	guanosine 5'-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
guanosine 3',5'-cyclic phosphate + H2O	-	Homo sapiens	guanosine 5'-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
cGMP-binding cGMP-specific phosphodiesterase	-	Homo sapiens
PDE5	-	Homo sapiens

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Release 2023.1 (January 2023)