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Literature summary for 3.1.4.35 extracted from
- Noncatalytic cGMP-binding sites of amphibian rod cGMP phosphodiesterase control interaction with its inhibitory gamma-subunits (1992), J. Biol. Chem., 267, 24501-24507.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| GTP | - |
Lithobates catesbeianus |  |
| GTP | - |
Rhinella marina | |
| GTP | - |
Lithobates grylio | |
| light | activation by a rod G-protein | Lithobates catesbeianus | |
| light | activation by a rod G-protein | Rhinella marina | |
| light | activation by a rod G-protein | Lithobates grylio |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Inhibitor protein | - |
Lithobates catesbeianus | |
| Inhibitor protein | gamma-subunit of enzyme | Lithobates grylio | |
| Inhibitor protein | gamma-subunit of enzyme | Rhinella marina |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| photoreceptor outer segment | rod outer segment | Lithobates catesbeianus | 1750 | - |
| photoreceptor outer segment | rod outer segment | Rhinella marina | 1750 | - |
| photoreceptor outer segment | rod outer segment | Lithobates grylio | 1750 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Lithobates catesbeianus | - |
bullfrog | - |
| Lithobates grylio | - |
- |
- |
| Rhinella marina | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| retina | - |
Lithobates catesbeianus | - |
| retina | - |
Rhinella marina | - |
| retina | - |
Lithobates grylio | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3',5'-cGMP + H2O | - |
Lithobates catesbeianus | 5'-GMP | - |
? | |
| 3',5'-cGMP + H2O | - |
Rhinella marina | 5'-GMP | - |
? | |
| 3',5'-cGMP + H2O | - |
Lithobates grylio | 5'-GMP | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | an alpha- and beta-subunit, catalytic and two identical gamma subunits, noncatalytic, no method mentioned | Lithobates catesbeianus |
| tetramer | an alpha- and beta-subunit, catalytic and two identical gamma subunits, noncatalytic, no method mentioned | Rhinella marina |
| tetramer | an alpha- and beta-subunit, catalytic and two identical gamma subunits, noncatalytic, no method mentioned | Lithobates grylio |
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