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Literature summary for 3.1.4.3 extracted from

  • Strielkov, I.V.; Kizub, I.V.; Khromov, A.S.; Soloviev, A.I.
    Evidence for the role of phosphatidylcholine-specific phospholipase C in sustained hypoxic pulmonary vasoconstriction (2013), Vascul. Pharmacol., 58, 292-298.
    View publication on PubMed
Search for more literature for 3.1.4.3

Inhibitors

Inhibitors Comment Organism Structure
tricyclodecan-9-yl-xanthogenate i.e. D609, a specific inhibitor, prevents the development of acute hypoxic pulmonary hypertension in rats, and also inhibits pulmonary vasoconstriction induced with a generator of superoxide anions LY83583, but not the one induced with hydrogen peroxide Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + H2O Rattus norvegicus
-
 1,2-sn-diacylglycerol + phosphocholine
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
artery intrapulmonary arteries Rattus norvegicus
-
lung
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + H2O
-
 Rattus norvegicus 1,2-sn-diacylglycerol + phosphocholine
-
 ?

Synonyms

Synonyms Comment Organism
PC-PLC
-
 Rattus norvegicus
phosphatidylcholine-specific phospholipase C
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function the enzyme plays an important role in sustained hypoxic pulmonary vasoconstriction possibly through the activation of protein kinase C-independent mechanism, which may be coupled with phosphocholine release. Phosphocholine induces sustained contraction in isolated intrapulmonary arteries and also transient pulmonary and systemic hypertension if administered intravenously Rattus norvegicus