Inhibitors | Comment | Organism | Structure |
---|---|---|---|
tricyclodecan-9-yl-xanthogenate | i.e. D609, a specific inhibitor, significantly suppresses the (S)-3-methyl-2-phenyl-N-(1-phenylpropyl)-4-quinolinecarboxamide-induced current in type I nNOS neurons | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + H2O | Mus musculus | - |
1,2-sn-diacylglycerol + phosphocholine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
glutamate decarboxylase 67-green fluorescent protein, GAD67-GFP, knock-in mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | GFP-positive visual cortical neurons, type I nNOS neurons | Mus musculus | - |
visual cortex | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + H2O | - |
Mus musculus | 1,2-sn-diacylglycerol + phosphocholine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PC-PLC | - |
Mus musculus |
phosphatidylcholine-specific phospholipase C | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
metabolism | (S)-3-methyl-2-phenyl-N-(1-phenylpropyl)-4-quinolinecarboxamide activates TRP-like ion channels through an phosphatidylcholine-specific phospholipase C-dependent signaling pathway, mechanism, overview | Mus musculus |
physiological function | the enzyme is involved in the regulation of Ca2+-permeable nonselective cation channels. (S)-3-methyl-2-phenyl-N-(1-phenylpropyl)-4-quinolinecarboxamide-induced current is mediated by the enzyme in neuronal nitric oxide synthase-expressing, GFP-responsive GABAergic neurons of the visual neocortex. (S)-3-methyl-2-phenyl-N-(1-phenylpropyl)-4-quinolinecarboxamide-induced current is mediated by G proteins and suppressed by D609, an inhibitor of phosphatidylcholine-specific phospholipase C, but not by inhibitors of phosphatidylinositol-specific phospholipase C, EC 3.1.4.11, adenylate cyclase or Src tyrosine kinases | Mus musculus |