Activating Compound | Comment | Organism | Structure |
---|---|---|---|
methylmercury | MeHg, activation of PLC | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D609 | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus C57BL/6 | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glia | primary | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
PC-PLC | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | PLC activation initiates the calcium signaling system. Phospholipase C activity is necessary for methylmercury-induced interleukin-6 release. Sustained interleukin-6 exposure can be detrimental to cerebellar granule neurons, one of the major cellular targets of methylmercury cytotoxicity | Mus musculus |