Literature summary for 3.1.4.3 extracted from

Flores-Diaz, M.; Alape-Giron, A.; Clark, G.; Catimel, B.; Hirabayashi, Y.; Nice, E.; Gutierrez, J.M.; Titball, R.; Thelestam, M.
A Cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C (2005), J. Biol. Chem., 280, 26680-26689.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Clostridium perfringens	the enzyme is the major virulence factor in the pathogenesis of gas gangrene. Reduction in gangliosides renders cells more susceptible to the membrane f´damage caused by Cp-PLC	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Clostridium perfringens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is the major virulence factor in the pathogenesis of gas gangrene. Reduction in gangliosides renders cells more susceptible to the membrane f´damage caused by Cp-PLC	Clostridium perfringens	?	-	?

Synonyms

Synonyms	Comment	Organism
alpha-toxin	-	Clostridium perfringens

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Release 2023.1 (January 2023)