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Literature summary for 3.1.4.3 extracted from

  • Hanada, K.; Palacpac, N.M.Q.; Magistrado, P.A.; Kurokawa, K.; Rai, G.; Sakata, D.; Hara, T.; Horii, T.; Nishijima, M.; Mitamura, T.
    Plasmodium falciparum phospholipase C hydrolyzing sphingomyelin and lysocholinephospholipids is a possible target for malaria chemotherapy (2002), J. Exp. Med., 195, 23-34.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.3

Activating Compound

Activating Compound Comment Organism Structure
Mg2+ required Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
scyphostatin 50% inhibition of parasite-growth at 0.007 mM Plasmodium falciparum
sphingomyelin competitive Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.025
-
 1-palmitoyl-lysophosphatidylcholine pH 7.5, 37°C Plasmodium falciparum
0.09
-
 sphingomyelin pH 7.5, 37°C Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane associated to Plasmodium falciparum 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
46000
-
 x * 46000, deduced from gene sequence Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-palmitoyl-lysophosphatidylcholine + H2O
-
 Plasmodium falciparum monopalmitoylglycerol + phosphorylcholine
-
 ?
lysocholinephospholipid + H2O
-
 Plasmodium falciparum ?
-
 ?
sphingomyelin + H2O
-
 Plasmodium falciparum ceramide + phosphocholine
-
 ?

Subunits

Subunits Comment Organism
? x * 46000, deduced from gene sequence Plasmodium falciparum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Plasmodium falciparum