Literature summary for 3.1.4.3 extracted from

Vitale, M.; Matteucci, A.; Manzoli, L.; Rodella, L.; Mariani, A.R.; Zauli, G.; Falconi, M.; Billi, A.M.; Martelli, A.M.; Gilmour, R.S.; Cocco, L.
Interleukin-2 activates nuclear phospholipase-Cb by mitogen-activated protein kinase-dependent phosphorylation in human natural killer cells (2001), FASEB J., 15, 1789-1791.

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Activating Compound

Activating Compound	Comment	Organism	Structure
IL-2	stimulates isoform beta1 in vivo within 60 min of treatment	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	inhibition of enzyme leads to inhibition of IL-2 induced proliferation of cells	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isozyme PLC-Cbeta	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	serine-phosphorylation of enzyme after treatment with IL-2, phosphorylation is abolished after MAPK inhibition	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
natural killer cell	primary natural killer cell	Homo sapiens	-

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Release 2023.1 (January 2023)