Cloned (Comment) | Organism |
---|---|
PDE3A expression in HEK-293 cells on the plasma membrane | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
adenosine | - |
Homo sapiens | |
adenosine | - |
Sus scrofa | |
cilostazol | a PDE3 inhibitor | Homo sapiens | |
cilostazol | a PDE3 inhibitor | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Homo sapiens | 5886 | - |
plasma membrane | - |
Sus scrofa | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | PDE3A physically and functionally interacts with cystic fibrosis transmembrane conductance regulator, CFTR, channel | ? | - |
? | |
additional information | Sus scrofa | PDE3A physically and functionally interacts with cystic fibrosis transmembrane conductance regulator, CFTR, channel | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Calu-3 cell | - |
Homo sapiens | - |
epithelial cell | - |
Homo sapiens | - |
epithelial cell | - |
Sus scrofa | - |
lung | trachea submucosal gland | Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PDE3A physically and functionally interacts with cystic fibrosis transmembrane conductance regulator, CFTR, channel | Homo sapiens | ? | - |
? | |
additional information | PDE3A physically and functionally interacts with cystic fibrosis transmembrane conductance regulator, CFTR, channel | Sus scrofa | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDE3A | - |
Homo sapiens |
PDE3A | - |
Sus scrofa |
phosphodiesterase type 3A | - |
Homo sapiens |
phosphodiesterase type 3A | - |
Sus scrofa |
General Information | Comment | Organism |
---|---|---|
physiological function | PDE3A physically and functionally interacts with cystic fibrosis transmembrane conductance regulator, CFTR, channel. PDE3A inhibition generates compartmentalized cAMP, which further clusters PDE3A and CFTR into microdomains at the plasma membrane and potentiates CFTR channel function. Actin skeleton disruption reduces PDE3A-CFTR interaction and segregates PDE3A from its interacting partners, thus compromising the integrity of the CFTR-PDE3A-containing macromolecular complex, compartmentalized cAMP signaling is lost | Homo sapiens |
physiological function | PDE3A physically and functionally interacts with cystic fibrosis transmembrane conductance regulator, CFTR, channel. PDE3A inhibition generates compartmentalized cAMP, which further clusters PDE3A and CFTR into microdomains at the plasma membrane and potentiates CFTR channel function. Actin skeleton disruption reduces PDE3A-CFTR interaction and segregates PDE3A from its interacting partners, thus compromising the integrity of the CFTR-PDE3A-containing macromolecular complex, compartmentalized cAMP signaling is lost | Sus scrofa |