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Literature summary for 3.1.4.17 extracted from

  • Brown, D.M.; Hutchison, L.; Donaldson, K.; MacKenzie, S.J.; Dick, C.A.; Stone, V.
    The effect of oxidative stress on macrophages and lung epithelial cells: the role of phosphodiesterases 1 and 4 (2007), Toxicol. Lett., 168, 1-6.
    View publication on PubMed

Application

Application Comment Organism
medicine reactive oxygen-species mediated lung inflammation may be mediated at least in part by calcium and elevated enzyme activity associated with decreased caMP in both macorphages and epithelial cells Mus musculus
medicine reactive oxygen-species mediated lung inflammation may be mediated at least in part by calcium and elevated enzyme activity associated with decreased caMP in both macorphages and epithelial cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information treatment with oxidant t-butylhydroperoxide results in release of significant amounts of interleukin-8, which is prevented by inhibition of enzyme isoforms PDE1 and PDE4 Homo sapiens
additional information the oxidant t-butylhydroperoxide signifcantly increases the cytosolic calcium concentration, which is prevented by inhibition of enzyme isoform PDE1. Inhibition of both isoforms PDE1 and PDE4 completely prevent the t-butylhydroperoxide stimulated TNF-alpha release Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isoform PDE1
-
Mus musculus
-
isoform PDE1
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell lung epithelial cell Homo sapiens
-
J-774 cell macrophage cell Mus musculus
-