Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.4.17 extracted from

  • Gross-Langenhoff, M.; Hofbauer, K.; Weber, J.; Schultz, A.; Schultz, J.E.
    cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11 (2006), J. Biol. Chem., 281, 2841-2846.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information chimera of isoform PDE10 GAF-domain and cyanobacterial cyclase is stimulated 9fold by cAMP, whereas cGMP has only low activity. CAMP increases Vmax in a non-cooperative manner and does not influence the Km value. Mutation of the D residue within the invariant NKFDE motif of the GAF domain reduces intramolecular signaling considerably Homo sapiens
additional information chimera of isoform PDE11 GAF-domain and cyanobacterial cyclase shows non-cooperative 4fold increase in Vmax. Mutation of the D residue within the invariant NKFDE motif of the GAF domain reduces intramolecular signaling considerably Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9HCR9 isoform PDE11A4
-
Homo sapiens Q9Y233 isoform PDE10A1
-