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Literature summary for 3.1.4.17 extracted from

  • Guerra de Gonzalez, L.; Gonzalez de Alfonzo, R.; Lippo de Becemberg, I.; Alfonzo, M.J.
    Cyclic nucleotide-dependent phosphodiesterases (PDEI) inhibition by muscarinic antagonists in bovine tracheal smooth muscle (2004), Biochem. Pharmacol., 68, 651-658.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bos taurus muscarinic antagonists acting possibly as inverse agonists on M2/M3 muscarinic acetylcholine receptors anchored to sarcolemma membranes can initiate a new signal transducing cascade leading to inhibition of PDEI, which produces a simultaneous rise in both cAMP and cGMP intracellular levels in tracheal smooth muscle ?
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?

Organism

Organism UniProt Comment Textmining
Bos taurus
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Source Tissue

Source Tissue Comment Organism Textmining
tracheal smooth muscle
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Bos taurus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information muscarinic antagonists acting possibly as inverse agonists on M2/M3 muscarinic acetylcholine receptors anchored to sarcolemma membranes can initiate a new signal transducing cascade leading to inhibition of PDEI, which produces a simultaneous rise in both cAMP and cGMP intracellular levels in tracheal smooth muscle Bos taurus ?
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?

Synonyms

Synonyms Comment Organism
PDEI
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Bos taurus