BRENDA - Enzyme Database
show all sequences of 3.1.4.17

Identification and characterization of a human calmodulin-stimulated phosphodiesterase PDE1B1

Yu, J.; Wolda, S.L.; Frazier, A.L.B.; Florio, V.A.; Martins, T.J.; Snyder, P.B.; Harris, E.A.S.; McCaw, K.N.; Farrell, C.A.; Steiner, B.; Bentley J.K.; Beavo, J.A.; Ferguson, K.; Gelinas, R.; Cell. Signal. 9, 519-529 (1997)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
expression in Saccharomyces cerevisiae
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
3-isobutyl-1-methylxanthine
-
Homo sapiens
8-methoxymethyl(-3-isobutyl-1-)methylxanthine
-
Homo sapiens
Cilostamide
-
Homo sapiens
rolipram
-
Homo sapiens
vinpocetine
-
Homo sapiens
zaprinast
-
Homo sapiens
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
Ca2+/calmodulin stimulated
Homo sapiens
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
Q01064
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
3',5'-cGMP + H2O
-
135268
Homo sapiens
5'-GMP
-
-
-
?
nucleoside 3',5'-cyclic phosphate + H2O
-
135268
Homo sapiens
nucleoside 5'-phosphate
-
135268
Homo sapiens
?
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Saccharomyces cerevisiae
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
3-isobutyl-1-methylxanthine
-
Homo sapiens
8-methoxymethyl(-3-isobutyl-1-)methylxanthine
-
Homo sapiens
Cilostamide
-
Homo sapiens
rolipram
-
Homo sapiens
vinpocetine
-
Homo sapiens
zaprinast
-
Homo sapiens
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
Ca2+/calmodulin stimulated
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
3',5'-cGMP + H2O
-
135268
Homo sapiens
5'-GMP
-
-
-
?
nucleoside 3',5'-cyclic phosphate + H2O
-
135268
Homo sapiens
nucleoside 5'-phosphate
-
135268
Homo sapiens
?
Other publictions for EC 3.1.4.17
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)