Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
neutral sphingomyelinase-2 | - |
Homo sapiens |
nSMase2 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | all-trans-retinoic acid induces nSMase2 | up |
General Information | Comment | Organism |
---|---|---|
metabolism | all-trans-retinoic acid induction of nSMase2 stimulates an increase in ceramide levels followed by G0/G1 growth arrestin MCF-7 cells. nSMase2 siRNA significantly inhibits all-trans-retinoic acid effects on ceramide levels and growth arrest. Neither all-trans-retinoic acid stimulation nor nSMase2 overexpression have significant effects on classical cell cycle regulators such as p21/WAF1 or retinoblastoma. In contrast, all-trans-retinoic acid suppresses phosphorylation of ribosomal S6 kinase and its downstream targets S6 and eIF4B, which is significantly inhibited by nSMase2 siRNA. nSMase2 overexpression is sufficient to suppress S6K phosphorylation and signaling | Homo sapiens |
physiological function | all-trans-retinoic acid regulation of nSMase2, overview | Homo sapiens |