Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-acetyl-11-keto-beta-boswellic acid | 62% inhibition of acid SMase at 0.1 mM | Homo sapiens | |
additional information | 3-acetyl-11-keto-beta-boswellic acid does not inhibit neutral or alkaline SMase activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2 cell | - |
Homo sapiens | - |
intestine | - |
Homo sapiens | - |
intestine-407 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | - |
Homo sapiens | N-acylsphingosine + choline phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acid SMase | - |
Homo sapiens |
acid sphingomyelinase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.05 | - |
acid SMase | Homo sapiens | 3-acetyl-11-keto-beta-boswellic acid |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | 3-acetyl-11-keto-beta-boswellic acid inhibits expression of acid sphingomyelinase in intestinal cells at high concentration 3-acetyl-11-keto-beta-boswellic acid decreases both the mass of acid SMase protein and the mRNA levels of acid SMase in the cells | down |