Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | feeding psyllium, a water-soluble fiber, increases Alk-SMase and decreases N-CDase activity, and thus might enhance ceramide levels in the intestinal mucosa | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CHAPS | CHAPS and Triton X-100 that are commonly used in acid and neutral SMase assays, do not stimulate but rather strongly inhibit the bile salt-induced activation of Alk-SMase | Homo sapiens | |
CHAPS | CHAPS and Triton X-100 that are commonly used in acid and neutral SMase assays, do not stimulate but rather strongly inhibit the bile salt-induced activation of Alk-SMase | Mus musculus | |
CHAPS | CHAPS and Triton X-100 that are commonly used in acid and neutral SMase assays, do not stimulate but rather strongly inhibit the bile salt-induced activation of Alk-SMase | Rattus norvegicus | |
additional information | Alk-SMase is resistant to trypsin digestion | Homo sapiens | |
additional information | Alk-SMase is resistant to trypsin digestion | Mus musculus | |
additional information | Alk-SMase is resistant to trypsin digestion | Rattus norvegicus | |
Triton X-100 | CHAPS and Triton X-100 that are commonly used in acid and neutral SMase assays, do not stimulate but rather strongly inhibit the bile salt-induced activation of Alk-SMase | Homo sapiens | |
Triton X-100 | CHAPS and Triton X-100 that are commonly used in acid and neutral SMase assays, do not stimulate but rather strongly inhibit the bile salt-induced activation of Alk-SMase | Mus musculus | |
Triton X-100 | CHAPS and Triton X-100 that are commonly used in acid and neutral SMase assays, do not stimulate but rather strongly inhibit the bile salt-induced activation of Alk-SMase | Rattus norvegicus | |
Zn2+ | Alk-SMase | Homo sapiens | |
Zn2+ | Alk-SMase | Mus musculus | |
Zn2+ | Alk-SMase | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Mus musculus | 5886 | - |
plasma membrane | - |
Homo sapiens | 5886 | - |
plasma membrane | - |
Rattus norvegicus | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | Alk-SMase reduces the lysophosphatidic acid formation by hydrolyzing lysophosphatidylcholine to monoacylglycerol, potential biological functions, overview | ? | - |
? | |
additional information | Homo sapiens | Alk-SMase reduces the lysophosphatidic acid formation by hydrolyzing lysophosphatidylcholine to monoacylglycerol, potential biological functions, overview | ? | - |
? | |
additional information | Rattus norvegicus | Alk-SMase reduces the lysophosphatidic acid formation by hydrolyzing lysophosphatidylcholine to monoacylglycerol, potential biological functions, overview | ? | - |
? | |
sphingomyelin + H2O | Mus musculus | Alk-SMase activity decreases with age, both Alk-SMase and N-CDase play a role in the regulation of cholesterol absorption in the small intestine, as the sphingosine in the gut is a product of a concerted action of these two enzymes, mechanism, overview | N-acylsphingosine + choline phosphate | - |
? | |
sphingomyelin + H2O | Rattus norvegicus | Alk-SMase activity decreases with age, both Alk-SMase and N-CDase play a role in the regulation of cholesterol absorption in the small intestine, as the sphingosine in the gut is a product of a concerted action of these two enzymes, mechanism, overview | N-acylsphingosine + choline phosphate | - |
? | |
sphingomyelin + H2O | Homo sapiens | Alk-SMase activity decreases with age, both Alk-SMase and N-CDase play a role in the regulation of cholesterol absorption in the small intestine, as the sphingosine in the gut is a product of a concerted action of these two enzymes, mechanism, overview, dietary SM inhibits colonic carcinogenesis by a mechanism related to SM digestion in the gut, overview | N-acylsphingosine + choline phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | high activity | Mus musculus | - |
colon | high activity | Homo sapiens | - |
colon | high activity | Rattus norvegicus | - |
colonic cancer cell | - |
Mus musculus | - |
colonic cancer cell | - |
Homo sapiens | - |
colonic cancer cell | - |
Rattus norvegicus | - |
gastrointestinal tract | - |
Mus musculus | - |
gastrointestinal tract | - |
Homo sapiens | - |
gastrointestinal tract | - |
Rattus norvegicus | - |
gut | - |
Mus musculus | - |
gut | - |
Homo sapiens | - |
gut | - |
Rattus norvegicus | - |
jejunum | low activity | Mus musculus | - |
jejunum | low activity | Homo sapiens | - |
jejunum | low activity | Rattus norvegicus | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
additional information | Alk-SMase developmental enzyme activity, overview, Alk-SMase activity decreases with age | Mus musculus | - |
additional information | Alk-SMase developmental enzyme activity, overview, Alk-SMase activity decreases with age | Homo sapiens | - |
additional information | Alk-SMase developmental enzyme activity, overview, Alk-SMase activity decreases with age | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Alk-SMase reduces the lysophosphatidic acid formation by hydrolyzing lysophosphatidylcholine to monoacylglycerol, potential biological functions, overview | Mus musculus | ? | - |
? | |
additional information | Alk-SMase reduces the lysophosphatidic acid formation by hydrolyzing lysophosphatidylcholine to monoacylglycerol, potential biological functions, overview | Homo sapiens | ? | - |
? | |
additional information | Alk-SMase reduces the lysophosphatidic acid formation by hydrolyzing lysophosphatidylcholine to monoacylglycerol, potential biological functions, overview | Rattus norvegicus | ? | - |
? | |
sphingomyelin + H2O | - |
Mus musculus | N-acylsphingosine + choline phosphate | - |
? | |
sphingomyelin + H2O | - |
Homo sapiens | N-acylsphingosine + choline phosphate | - |
? | |
sphingomyelin + H2O | - |
Rattus norvegicus | N-acylsphingosine + choline phosphate | - |
? | |
sphingomyelin + H2O | Alk-SMase activity decreases with age, both Alk-SMase and N-CDase play a role in the regulation of cholesterol absorption in the small intestine, as the sphingosine in the gut is a product of a concerted action of these two enzymes, mechanism, overview | Mus musculus | N-acylsphingosine + choline phosphate | - |
? | |
sphingomyelin + H2O | Alk-SMase activity decreases with age, both Alk-SMase and N-CDase play a role in the regulation of cholesterol absorption in the small intestine, as the sphingosine in the gut is a product of a concerted action of these two enzymes, mechanism, overview | Rattus norvegicus | N-acylsphingosine + choline phosphate | - |
? | |
sphingomyelin + H2O | Alk-SMase activity decreases with age, both Alk-SMase and N-CDase play a role in the regulation of cholesterol absorption in the small intestine, as the sphingosine in the gut is a product of a concerted action of these two enzymes, mechanism, overview, dietary SM inhibits colonic carcinogenesis by a mechanism related to SM digestion in the gut, overview | Homo sapiens | N-acylsphingosine + choline phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acid SMase | - |
Mus musculus |
acid SMase | - |
Homo sapiens |
acid SMase | - |
Rattus norvegicus |
alk-SMase | - |
Mus musculus |
alk-SMase | - |
Homo sapiens |
alk-SMase | - |
Rattus norvegicus |
neutral SMase | - |
Mus musculus |
neutral SMase | - |
Homo sapiens |
neutral SMase | - |
Rattus norvegicus |
SMase | - |
Mus musculus |
SMase | - |
Homo sapiens |
SMase | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9 | - |
- |
Mus musculus |
9 | - |
- |
Homo sapiens |
9 | - |
- |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 10.5 | - |
Mus musculus |
6 | 10.5 | - |
Homo sapiens |
6 | 10.5 | - |
Rattus norvegicus |