Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ceramide | feedback inhibition | Bacillus cereus | |
palmitate | a non-substrate lipid belonging to the phospholipase A2 pathway | Bacillus cereus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | different SMase kinetic steps are differentially regulated by non-substrate lipids, overview | Bacillus cereus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Bacillus cereus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | plays a role in enzyme regulation by non-substrate lipids | Bacillus cereus | |
Mg2+ | dependent on, best at 3 mM | Bacillus cereus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | Bacillus cereus | changes in the initial composition and topography of mixed monolayers of sphingomyelin and ceramide modulate the sphingomyelin degradation by the enzyme, overview, the enzyme in an extracellular toxin that exhibits potent hemolytic activity against sphingomyelin-rich erythrocytes in mammals | N-acylsphingosine + choline phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus cereus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Bacillus cereus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | changes in the initial composition and topography of mixed monolayers of sphingomyelin and ceramide modulate the sphingomyelin degradation by the enzyme, overview, the enzyme in an extracellular toxin that exhibits potent hemolytic activity against sphingomyelin-rich erythrocytes in mammals | Bacillus cereus | N-acylsphingosine + choline phosphate | - |
? | |
sphingomyelin + H2O | SMase shows very low activity against condensed sphingomyelin, but is active on loosely organized sphingomyelin in bilayers and monolayers, overview | Bacillus cereus | N-acylsphingosine + choline phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the enzyme structure and topology influences the enzyme activity, overview | Bacillus cereus |
Synonyms | Comment | Organism |
---|---|---|
neutral SMase | - |
Bacillus cereus |
SMase | - |
Bacillus cereus |
sphingomyelinase | - |
Bacillus cereus |