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Literature summary for 3.1.4.12 extracted from
- Overexpression of acid sphingomyelinase sensitizes glioma cells to chemotherapy (2007), Antioxid. Redox Signal., 9, 1449-1456.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | activation of acid sphingomyelinase by gemcitabine or doxorubicin, respectively, via reactive oxygen species | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| transfection of murine and human glioma cell lines Gl-261 and U-373 with acid sphingomyelinase results in a marked sensitization of glioma cells to gemcitabine and doxorubicin, respectively | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acid sphingomyelinase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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