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Literature summary for 3.1.4.11 extracted from

  • Sturgeon, R.M.; Magoski, N.S.
    A closely associated phospholipase C regulates cation channel function through phosphoinositide hydrolysis (2018), J. Neurosci., 38, 7622-7634 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.11

Activating Compound

Activating Compound Comment Organism Structure
N-(3-trifluoromethyl-phenyl)-2,4,6-trimethylbenzenesulfonamide
-
 Aplysia californica

Inhibitors

Inhibitors Comment Organism Structure
U-73122
-
 Aplysia californica

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane the enzyme associates with the cation channel in excised patches Aplysia californica 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Aplysia californica
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 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?

Organism

Organism UniProt Comment Textmining
Aplysia californica
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bag cell neuron
-
 Aplysia californica
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Aplysia californica 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?

Synonyms

Synonyms Comment Organism
phospholipase C
-
 Aplysia californica
PLC
-
 Aplysia californica

General Information

General Information Comment Organism
physiological function enzyme-mediated lipid signaling controls single-channel currents to ensure depolarization is maintained for an extended period of firing, termed the after discharge, when the bag cell neurons secrete egg-laying hormone to trigger reproduction. Enzyme-mediated 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown products modulate cation channel activity and left-shift cation channel voltage dependence Aplysia californica