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Literature summary for 3.1.4.11 extracted from
- Phospholipase Cepsilon is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation (2007), Proc. Natl. Acad. Sci. USA, 104, 15543-15548.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | PLCepsilon is required for thrombin- but not lysophosphatidic acid-induced sustained ERK activation and DNA synthesis, providing a novel mechanism for G protein-coupled receptor and Rho signaling to cell proliferation. PLCepsilon has a role as a guanine nucleotide exchange factor for Rap1 | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q8K4S1 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | PLCepsilon is required for thrombin- but not lysophosphatidic acid-induced sustained ERK activation and DNA synthesis, providing a novel mechanism for G protein-coupled receptor and Rho signaling to cell proliferation. PLCepsilon has a role as a guanine nucleotide exchange factor for Rap1 | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phospholipase Cepsilon | - |
Mus musculus |
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Release 2023.1 (January 2023)
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