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Literature summary for 3.1.4.11 extracted from

  • Cocco, L.; Martelli, A.M.; Mazzotti, G.; Barnabei, O.; Manzoli, F.A.
    Inositides and the nucleus: phospholipase Cbeta family localization and signaling activity (2000), Adv. Enzyme Regul., 40, 83-95.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
insulin-like growth factor 1 stimulates nuclear PLCbeta1, through translocation of MAP kinase to the nucleus Mus musculus
MAP kinase phosphorylates and activates nuclear PLCbeta1 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus all the four isoenzymes of the beta family are detectable in nuclei, beta1, beta2, beta3 and beta4, but not PLCgamma and PLCdelta, membrane deprived nuclei possess a higher amount of PLCs, beta isoenzymes are localized in the inner nuclear compartment and not in the nuclear envelope Mus musculus 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Mus musculus PLCbeta1 is involved in nuclear inositol lipid signaling 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
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?

Organism

Organism UniProt Comment Textmining
Mus musculus
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PLCbeta1
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein increased phosphorylation of nuclear PLCbeta1, due to nuclear translocation of MAP kinase, is required for the activation of the nuclear inositol lipid cycle in 3T3 cells treated with insulin-like growth factor 1 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
NIH-3T3 cell fibroblasts, treated with insulin-like growth factor 1 Mus musculus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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PLC beta isoenzymes, activities in membrane deprived and intact nuclei Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
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Mus musculus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
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?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O PLCbeta1 is involved in nuclear inositol lipid signaling Mus musculus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
?

Synonyms

Synonyms Comment Organism
More ten mammalian isoenzymes, grouped into three families: PLCbeta, PLCgamma and PLCdelta Mus musculus