Any feedback?
Literature summary for 3.1.4.11 extracted from
- The inhibition and activation of Ca2+-dependent phosphatidylinositol phosphodiesterase by phospholipids and blood plasma (1980), Eur. J. Biochem., 112, 33-38.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| decanoylglycerophosphate | only little activating effect | Rattus norvegicus |  |
| decanoyllysophosphatidylcholine | C10 lysophosphatidylcholine activates the reaction | Rattus norvegicus | |
| dihexanoylglycerophosphocholine | - |
Rattus norvegicus | |
| oleoylglycerophosphate | activates the hydrolysis at a physiological pH | Rattus norvegicus | |
| palmitoylglycerophosphate | activates the hydrolysis at a physiological pH | Rattus norvegicus | |
| phosphatidic acid | activates the hydrolysis at a physiological pH | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Blood lipoprotein | enzyme is strongly inhibited by blood plasma, serum and blood lipoproteins | Rattus norvegicus | |
| Blood plasma | enzyme is strongly inhibited by blood plasma, serum and blood lipoproteins | Rattus norvegicus | |
| Blood serum | enzyme is strongly inhibited by blood plasma, serum and blood lipoproteins | Rattus norvegicus | |
| lysophosphatidylcholine | C12, C14 and C16 lysophosphatidylcholines give progressive inhibition with increasing chain length | Rattus norvegicus | |
| phosphatidylcholine | the enzyme is strongly inhibited when ovophosphatidylcholine and saturated phosphatidylcholines with acyl chain length of more than eight carbon atoms are mixed with its substrate | Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | required | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylinositol + H2O | - |
Rattus norvegicus | 1D-myo-inositol 1-phosphate + diacylglycerol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ca2 +-dependent phosphatidylinositol phosphodiesterase | - |
Rattus norvegicus |
| phosphatidylinositol phosphodiesterase | - |
Rattus norvegicus |
| phosphatidylinositol-phosphodiesterase | - |
Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
