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Literature summary for 3.1.4.11 extracted from

  • Hirasawa, K.; Irvine, R.F.; Dawson, R.M.C.
    The catabolism of phosphatidylinisitol by an EDTA-insensitive phospholipase A1 and calcium-dependent phosphatidylinositol phosphodiesterase in rat brain (1981), Eur. J. Biochem., 120, 53-58.
    View publication on PubMed
Search for more literature for 3.1.4.11

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-
microsome
-
 Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on, concentration of 5 mM CaCl2 produces optimum deacylation of phosphatidylinositol Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylinositol + H2O
-
 Rattus norvegicus 1D-myo-inositol 1-phosphate + glycerophosphoinositol + phosphate + ? ratio between products decreased with increasing pH, 1D-myo-inositol 1,2-cyclic phosphate is also formed ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol phosphodiesterase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
 activity at higher pH values requires higher calcium concentrations and disappears on purification of the soluble enzyme by ammonium sulfate fractionation Rattus norvegicus
5 5.5 extensive activity in the alkaline range (7-8.5) as well as at pH 5-5.5 Rattus norvegicus
7 8.5 extensive activity in the alkaline range (7-8.5) as well as at pH 5-5.5 Rattus norvegicus