Literature summary for 3.1.31.1 extracted from

Berends, E.T.; Horswill, A.R.; Haste, N.M.; Monestier, M.; Nizet, V.; von Koeckritz-Blickwede, M.
Nuclease expression by Staphylococcus aureus facilitates escape from neutrophil extracellular traps (2010), J. Innate Immun., 2, 576-586.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	required	Staphylococcus aureus
Mg2+	required	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	-	a community-acquired CA-MRSA strain, gene nuc	-
Staphylococcus aureus USA 300 LAC	-	a community-acquired CA-MRSA strain, gene nuc	-

Synonyms

Synonyms	Comment	Organism
staphylococcus aureus nuclease	-	Staphylococcus aureus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Staphylococcus aureus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Staphylococcus aureus

General Information

General Information	Comment	Organism
physiological function	Staphylococcus aureus nuclease mediates resistance against entrapment and killing within neutrophil extracellular traps, which consist of a nuclear DNA backbone associated with antimicrobial peptides, histones and proteases that provide a matrix to entrap and kill various microbes. Promoting role of Staphylococcus aureus nuclease in neutrophil extracellular traps degradation and virulence in a murine respiratory tract infection model, overview. Staphylococcus aureus nuclease facilitates evasion from neutrophil extracellular trap entrapment, and mediates resistance against extracellular killing by neutrophils	Staphylococcus aureus

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Release 2023.1 (January 2023)