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Literature summary for 3.1.31.1 extracted from

  • Hirano, S.; Kamikubo, H.; Yamazaki, Y.; Kataoka, M.
    Elucidation of information encoded in tryptophan 140 of staphylococcal nuclease (2005), Proteins, 58, 271-277.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
W140A DNA hydrolysis activity is 70% of wild-type activity Staphylococcus sp.
W140C DNA hydrolysis activity is 75% of wild-type activity Staphylococcus sp.
W140D DNA hydrolysis activity is 65% of wild-type activity Staphylococcus sp.
W140E DNA hydrolysis activity is 65% of wild-type activity Staphylococcus sp.
W140F native-like structure and native-like activity under physiological conditions Staphylococcus sp.
W140G DNA hydrolysis activity is 75% of wild-type activity Staphylococcus sp.
W140H native-like structure and native-like activity under physiological conditions Staphylococcus sp.
W140I DNA hydrolysis activity is 70% of wild-type activity Staphylococcus sp.
W140K DNA hydrolysis activity is 70% of wild-type activity Staphylococcus sp.
W140L DNA hydrolysis activity is 75% of wild-type activity Staphylococcus sp.
W140M DNA hydrolysis activity is 70% of wild-type activity Staphylococcus sp.
W140N DNA hydrolysis activity is 75% of wild-type activity Staphylococcus sp.
W140P DNA hydrolysis activity is 55% of wild-type activity Staphylococcus sp.
W140Q DNA hydrolysis activity is 75% of wild-type activity Staphylococcus sp.
W140R DNA hydrolysis activity is 75% of wild-type activity Staphylococcus sp.
W140S DNA hydrolysis activity is 75% of wild-type activity Staphylococcus sp.
W140T DNA hydrolysis activity is 75% of wild-type activity Staphylococcus sp.
W140V DNA hydrolysis activity is 75% of wild-type activity Staphylococcus sp.
W140Y native-like structure and native-like activity under physiological conditions Staphylococcus sp.

Organism

Organism UniProt Comment Textmining
Staphylococcus sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + H2O
-
Staphylococcus sp. 3'-deoxymononucleotides + dinucleotides
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
39
-
Tm-value of mutant enzyme W140F is 39.1°C, Tm-value of mutant enzyme W140Y is 38.6°C Staphylococcus sp.
42
-
Tm-value of mutant enzyme is 41.8°C Staphylococcus sp.
51
-
Tm-value of wild-type enzyme is 50.7°C Staphylococcus sp.