Literature summary for 3.1.3.B4 extracted from

Wood, C.S.; Hung, C.S.; Huoh, Y.S.; Mousley, C.J.; Stefan, C.J.; Bankaitis, V.; Ferguson, K.M.; Burd, C.G.
Local control of phosphatidylinositol 4-phosphate signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphatase (2012), Mol. Biol. Cell, 23, 2527-2536.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
Golgi apparatus	Vps74-Sac1 complexe is localised in the Golge apparatus	Saccharomyces cerevisiae	5794	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Saccharomyces cerevisiae	Vps74 (a PI4K effector required to maintain residence of a subset of Golgi proteins) binds directly to the catalytic domain of Sac1. Vps74 is a sensor of Pt¬dIns4P level on medial Golgi cisternae that directs Sac1-mediated dephosphosphorylation of this pool of PtdIns4P	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	Vps74 (a PI4K effector required to maintain residence of a subset of Golgi proteins) binds directly to the catalytic domain of Sac1. Vps74 is a sensor of Pt¬dIns4P level on medial Golgi cisternae that directs Sac1-mediated dephosphosphorylation of this pool of PtdIns4P	Saccharomyces cerevisiae	?	-	?

Synonyms

Synonyms	Comment	Organism
Sac1	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)