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Literature summary for 3.1.3.99 extracted from

  • Skladanowski, A.C.; Sala, G.B.; Newby, A.C.
    Inhibition of IMP-specific cytosolic 5'-nucleotidase and adenosine formation in rat polymorphonuclear leucocytes by 5'-deoxy-5'-isobutylthio derivatives of adenosine and inosine (1989), Biochem. J., 262, 203-208.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.99

Inhibitors

Inhibitors Comment Organism Structure
5'-deoxy-5'-isobutylthioadenosine noncompetitive inhibition Rattus norvegicus
5'-deoxy-5'-isobutylthioinosine noncompetitive inhibition Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
IMP + H2O Rattus norvegicus
-
 inosine + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-
polymorphonuclear leucocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IMP + H2O
-
 Rattus norvegicus inosine + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
IMP-specific cytosolic 5-nucleotidase
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
26
-
 at pH 7.4 and 37°C Rattus norvegicus 5'-deoxy-5'-isobutylthioadenosine
710
-
 at pH 7.4 and 37°C Rattus norvegicus 5'-deoxy-5'-isobutylthioinosine