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Literature summary for 3.1.3.95 extracted from

  • Pham, H.Q.; Yoshioka, K.; Mohri, H.; Nakata, H.; Aki, S.; Ishimaru, K.; Takuwa, N.; Takuwa, Y.
    MTMR4, a phosphoinositide-specific 3-phosphatase, regulates TFEB activity and the endocytic and autophagic pathways (2018), Genes Cells, 23, 670-687 .
    View publication on PubMed
Search for more literature for 3.1.3.95

Localization

Localization Comment Organism GeneOntology No. Textmining
autophagosome
-
 Homo sapiens 5776
-
endosome
-
 Homo sapiens 5768
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O Homo sapiens
-
 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 150000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
MTMR4
-
 Homo sapiens
myotubularin-related protein-4
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme knockdown markedly suppresses the motility, fusion, and fission of phosphatidylinositol 3-phosphate-enriched structures, resulting in decreases in late endosomes, autophagosomes, and lysosomes, and enlargement of phosphatidylinositol 3-phosphate-enriched early and late endosomes. Enzyme knockdown impairs starvation-induced transcription factor-EB nuclear translocation and lysosome biogenesis Homo sapiens