Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.92 extracted from

  • Vetter, N.D.; Langill, D.M.; Anjum, S.; Boisvert-Martel, J.; Jagdhane, R.C.; Omene, E.; Zheng, H.; van Straaten, K.E.; Asiamah, I.; Krol, E.S.; Sanders, D.A.; Palmer, D.R.
    A previously unrecognized kanosamine biosynthesis pathway in Bacillus subtilis (2013), J. Am. Chem. Soc., 135, 5970-5973.
    View publication on PubMed
Search for more literature for 3.1.3.92

Cloned(Commentary)

Cloned (Comment) Organism
expression in 'Escherichia coli Bacillus subtilis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.101
-
 kanosamine 6-phosphate pH not specified in the publication, temperature not specified in the publication Bacillus subtilis

Organism

Organism UniProt Comment Textmining
Bacillus subtilis O07565
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucosamine 6-phosphate + H2O about 1% of the activity with kanosamine 6-phosphate Bacillus subtilis D-glucosamine + phosphate
-
 ?
kanosamine 6-phosphate + H2O
-
 Bacillus subtilis kanosamine + phosphate
-
 ?
additional information no substrates: glucose 6-phosphate, 4-nitrophenyl phosphate, 3,3'-neotrehalosediamine 6-phosphate, 3,3'-neotrehalosediamine 6'-phosphate, 3,3'-neotrehalosediamine 6,6'-bisphosphate, glucose 1-phosphate Bacillus subtilis ?
-
 ?

Synonyms

Synonyms Comment Organism
ntdB
-
 Bacillus subtilis
yhjK
-
 Bacillus subtilis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
32
-
 kanosamine 6-phosphate pH not specified in the publication, temperature not specified in the publication Bacillus subtilis

General Information

General Information Comment Organism
physiological function the ntd operon is essential for biosynthesis of the unusual disaccharide 3,3'-neotrehalosadiamine. The enzymes catalyze the biosynthesis of kanosamine from glucose 6-phosphate. NtdC is a glucose-6-phosphate 3-dehydrogenase, NtdA is a pyridoxal phosphate-dependent 3-oxo-glucose-6-phosphate:glutamate aminotransferase, and NtdB is a kanosamine-6-phosphate phosphatase Bacillus subtilis