Literature summary for 3.1.3.9 extracted from

Kumar, M.; Rawat, P.; Khan, M.F.; Tamarkar, A.K.; Srivastava, A.K.; Arya, K.R.; Maurya, R.
Phenolic glycosides from Dodecadenia grandiflora and their glucose-6-phosphatase inhibitory activity (2010), Fitoterapia, 81, 475-479.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-[(4'-O-(E)-p-coumaroyl)-beta-D-glucopyranosyl]-oxy-2-phenol	-	Rattus norvegicus
1-[(6'-O-(E)-p-coumaroyl)-beta-D-glucopyranosyl]-oxy-2-phenol	-	Rattus norvegicus
1-[O-beta-D-glucopyranosyl(1->2)-beta-D-glucopyranosyl]-oxy-2-phenol	-	Rattus norvegicus
4-(beta-D-glucopyranosyloxy) benzoic acid	-	Rattus norvegicus
apigenin	-	Rattus norvegicus
apigenin-7-O-beta-D-glucopyranoside	-	Rattus norvegicus
apigenin-7-O-beta-D-glucuronic acid-6''-methyl ester	-	Rattus norvegicus
chlorogenic acid	-	Rattus norvegicus
itoside H	-	Rattus norvegicus
orthovanadate	-	Rattus norvegicus
pyrocatechol-O-beta-D-glucopyranoside	-	Rattus norvegicus
quercetin-3-O-beta-D-glucopyranoside	-	Rattus norvegicus
rutin	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-glucose 6-phosphate + H2O	-	Rattus norvegicus	D-glucose + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
D-glucose-6-phosphate phosphorylase	-	Rattus norvegicus
glucose-6-phosphatase	-	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
additional information	-	25.2% inhibition at 0.1 mM	Rattus norvegicus	1-[O-beta-D-glucopyranosyl(1->2)-beta-D-glucopyranosyl]-oxy-2-phenol
additional information	-	37.2% inhibition at 0.1 mM	Rattus norvegicus	apigenin-7-O-beta-D-glucuronic acid-6''-methyl ester
additional information	-	42.7% inhibition at 0.1 mM	Rattus norvegicus	apigenin-7-O-beta-D-glucopyranoside
0.05	-	85.4% inhibition at 0.1 mM	Rattus norvegicus	itoside H
0.051	-	82.9% inhibition at 0.1 mM	Rattus norvegicus	quercetin-3-O-beta-D-glucopyranoside
0.081	-	66.9% inhibition at 0.1 mM	Rattus norvegicus	1-[(6'-O-(E)-p-coumaroyl)-beta-D-glucopyranosyl]-oxy-2-phenol
0.0885	-	63.7% inhibition at 0.1 mM	Rattus norvegicus	1-[(4'-O-(E)-p-coumaroyl)-beta-D-glucopyranosyl]-oxy-2-phenol
0.091	-	56.1% inhibition at 0.1 mM	Rattus norvegicus	rutin
0.093	-	69.6% inhibition at 0.1 mM	Rattus norvegicus	chlorogenic acid
0.0935	-	53.4% inhibition at 0.1 mM	Rattus norvegicus	orthovanadate
0.095	-	51.8% inhibition at 0.1 mM	Rattus norvegicus	pyrocatechol-O-beta-D-glucopyranoside

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Release 2023.1 (January 2023)