Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme is positively regulated by a secreted multipolypeptide complex called counting factor, CF, or the CF component coutin, respectively | Dictyostelium discoideum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Dictyostelium discoideum | |
2.1 | - |
D-glucose 6-phosphate | pH 7.5, wild-type enzyme | Dictyostelium discoideum | |
2.1 | - |
D-glucose 6-phosphate | pH 7.5, coutin mutant enzyme | Dictyostelium discoideum | |
2.4 | - |
D-glucose 6-phosphate | pH 7.5, smlA mutant enzyme | Dictyostelium discoideum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Dictyostelium discoideum | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + H2O | Dictyostelium discoideum | the enzyme is the key enzyme of the gluconeogenesis pathway, and is positively regulated by a extracellular multipolypeptide complex called counting factor, CF, or the CF component coutin, respectively, while the glucokinase activity is inhibited by CF, regulation overview | D-glucose + phosphate | - |
? | |
additional information | Dictyostelium discoideum | cells of Dictyostelium discoideum form groups of about 20000 cells. The group size is regulated in part by a negative feedback pathway mediated by a secreted multipolypeptide complex called counting factor. It appears that part of the counting factor signal transduction pathway involves inhibiting the activity of glucose-6-phosphatase, decreasing intracellular glucose levels and affecting the levels of other metabolites, to regulate group size | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dictyostelium discoideum | - |
- |
- |
Dictyostelium discoideum | - |
wild-type strain AX4 and several mutant strains | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
metabolic activity in different strains, overview | Dictyostelium discoideum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + H2O | - |
Dictyostelium discoideum | D-glucose + phosphate | - |
? | |
D-glucose 6-phosphate + H2O | the enzyme is the key enzyme of the gluconeogenesis pathway, and is positively regulated by a extracellular multipolypeptide complex called counting factor, CF, or the CF component coutin, respectively, while the glucokinase activity is inhibited by CF, regulation overview | Dictyostelium discoideum | D-glucose + phosphate | - |
? | |
additional information | cells of Dictyostelium discoideum form groups of about 20000 cells. The group size is regulated in part by a negative feedback pathway mediated by a secreted multipolypeptide complex called counting factor. It appears that part of the counting factor signal transduction pathway involves inhibiting the activity of glucose-6-phosphatase, decreasing intracellular glucose levels and affecting the levels of other metabolites, to regulate group size | Dictyostelium discoideum | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Dictyostelium discoideum |