Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-alpha-aminocholestane | selective inhibitor of isoform SHIP-1 | Homo sapiens | |
AQX-1125 | Rosiptor, inhibitor of isoform SHIP-1 | Homo sapiens | |
NSC13480 | - |
Homo sapiens | |
NSC305787 | - |
Homo sapiens | |
sodium stibogluconate | inhibitor of isoform SHIP-1 | Homo sapiens | |
TNO155 | inhibitor of isoform SHIP-2 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O | Homo sapiens | - |
1-phosphatidyl-1D-myo-inositol 1,3,4-trisphosphate + phosphate | - |
? | |
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O | Homo sapiens | - |
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15357 | - |
- |
Homo sapiens | Q92835 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O | - |
Homo sapiens | 1-phosphatidyl-1D-myo-inositol 1,3,4-trisphosphate + phosphate | - |
? | |
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O | - |
Homo sapiens | 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 142000, isoform SHIP-2, SDS-PAGE | Homo sapiens |
? | x * 145000, isoform SHIP-1, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
INPP5D | - |
Homo sapiens |
INPPL1 | - |
Homo sapiens |
SHIP-1 | isoform | Homo sapiens |
SHIP-2 | isoform | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme deficiency leads to myeloproliferation and B-cell lymphoma in mice | Homo sapiens |
physiological function | the enzyme acts as a negative regulator of immune response and haematopoietic progenitor cell proliferation/survival, and as an inducer of cellular apoptosis. Isoform SHIP-1 is also implicated both as a haematopoietic tumour suppressor and activator | Homo sapiens |
physiological function | the enzyme acts as a negative regulator of immune response and haematopoietic progenitor cell proliferation/survival, and as an inducer of cellular apoptosis. Isoform SHIP-2 is a negative regulator of glucose homeostasis and is involved in the maturation and activation of mast cells as well as in phagocytosis directed by Fc receptors for immunoglobulin G, thus regulating allergic reactions and antibacterial defense | Homo sapiens |