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Literature summary for 3.1.3.86 extracted from

  • Eramo, M.J.; Mitchell, C.A.
    Regulation of PtdIns(3,4,5)P3/Akt signalling by inositol polyphosphate 5-phosphatases (2016), Biochem. Soc. Trans., 44, 240-252 .
    View publication on PubMed
Search for more literature for 3.1.3.86

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O Homo sapiens
-
 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O15357 isoform SHIP2
-
Homo sapiens Q92835 isoform SHIP1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 142000, isoform SHIP2, SDS-PAGE Homo sapiens
? x * 145000, isoform SHIP1, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
inositol polyphosphate 5-phosphatase
-
 Homo sapiens
SHIP1 isoform Homo sapiens
SHIP2 isoform Homo sapiens
Src homology 2-containing inositol phosphatase 1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function isoform SHIP1 inhibits haematopoietic cell proliferation, inhibits Akt signalling and regulates immune cell function in vitro and in vivo Homo sapiens
physiological function isoform SHIP2 regulates Akt signalling in metabolic tissues Homo sapiens