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Literature summary for 3.1.3.86 extracted from

  • Giuriato, S.; Payrastre, B.; Drayer, A.L.; Plantavid, M.; Woscholski, R.; Parker, P.; Erneux, C.; Chap, H.
    Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets (1997), J. Biol. Chem., 272, 26857-26863.
    View publication on PubMed
Search for more literature for 3.1.3.86

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-7 cells Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
145000
-
 gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein thrombin stimulation induces a tyrosine phosphorylation of SHIP Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PtdIns(3,4,5)-P3 phosphatase
-
 Homo sapiens
SH2 domain-containing inositol 5-phosphatase
-
 Homo sapiens
SHIP
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme activity is not increased after thrombin stimulation of COS-7 cells additional information

General Information

General Information Comment Organism
physiological function SHIP is involved in platelet activation evoked by thrombin Homo sapiens