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Literature summary for 3.1.3.83 extracted from
- Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB) (2010), Biochemistry, 49, 1072-1081.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Bacteroides thetaiotaomicron |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.033 | - |
D-glycero-alpha-D-manno-heptose 1,7-bisphosphate | pH 7.5, 25°C | Bacteroides thetaiotaomicron |  |
| 0.086 | - |
D-glycero-beta-D-manno-heptose 1,7-bisphosphate | pH 7.5, 25°C | Bacteroides thetaiotaomicron | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O | Bacteroides thetaiotaomicron | the likely function of the D-glycero-D-mannoheptose 1alpha-GDP pathway of Bacteroides thetaiotaomicron is to generate activated D-glycero-D-manno-heptose units for incorporation into the extracellular capsular polysaccharide | D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacteroides thetaiotaomicron | Q8AAI7 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bacteroides thetaiotaomicron |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O | the likely function of the D-glycero-D-mannoheptose 1alpha-GDP pathway of Bacteroides thetaiotaomicron is to generate activated D-glycero-D-manno-heptose units for incorporation into the extracellular capsular polysaccharide | Bacteroides thetaiotaomicron | D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate | - |
? | |
| D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O | kcat/Km for the alpha-anomer is 6fold higher than for the alpha-anomer | Bacteroides thetaiotaomicron | D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate | - |
? | |
| D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O | kcat/Km for the alpha-anomer is 6fold higher than for the alpha-anomer | Bacteroides thetaiotaomicron | D-glycero-beta-D-manno-heptose 1-phosphate + phosphate | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 13 | - |
D-glycero-beta-D-manno-heptose 1,7-bisphosphate | pH 7.5, 25°C | Bacteroides thetaiotaomicron | |
| 29 | - |
D-glycero-alpha-D-manno-heptose 1,7-bisphosphate | pH 7.5, 25°C | Bacteroides thetaiotaomicron | |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 151.1 | - |
D-glycero-beta-D-manno-heptose 1,7-bisphosphate | pH 7.5, 25°C | Bacteroides thetaiotaomicron | |
| 879 | - |
D-glycero-alpha-D-manno-heptose 1,7-bisphosphate | pH 7.5, 25°C | Bacteroides thetaiotaomicron | |
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