Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HUT-78 cell | - |
Homo sapiens | - |
T-lymphocyte | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
IpgD | - |
Homo sapiens |
PtdIns(4,5)P2 4-phosphatase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | phosphatidylinositol 5-phosphate may play a sensor function in setting the threshold of T-cell activation and contributing to maintain T-cell homeostasis | Homo sapiens |
physiological function | PtdIns(4,5)P2 4-phosphatase expression induces Src kinase and Akt, but not ERK activation and enhances interleukin II promoter activity in T-cells. Expression of a PtdIns5P interacting domain, PH-Dok-5, blocks IpgD-induced T-cell activation and selective signaling molecules downstream of TCR triggering, evaluation, overview | Homo sapiens |