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Literature summary for 3.1.3.78 extracted from

  • Zou, J.; Marjanovic, J.; Kisseleva, M.V.; Wilson, M.; Majerus, P.W.
    Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis (2007), Proc. Natl. Acad. Sci. USA, 104, 16834-16839.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
etoposide significantly increases type I 4-phosphatase in the nuclear fraction, in both the endogenous and overexpression system Homo sapiens

Application

Application Comment Organism
medicine type I 4-phosphatase regulates nuclear phosphatidylinositol 5-phosphate levels, which in turn mediate p53-dependent apoptosis through interaction with inhibitor of growth protein-2 in response to genotoxic stress Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
stably transfected HEK-293 TRex cells in a tetracycline-inducible vector expressing type I and II 4-phosphatase Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
PIPKIIbeta inhibits p53 acetylation and cell death Homo sapiens
RNAi siRNA of type I 4-phosphatase reduces type I 4-phosphatase levels, which is followed by a dramatic decrease in p53 levels in response to the genotoxic agent etoposide. siRNA of type II 4-phosphatase does not reduce p53 expression Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus when HeLa cells are treated with etoposide or doxorubicin, type I 4-phosphatase translocates to the nucleus and nuclear levels of phosphatidylinositol 5-phosphate increase Homo sapiens 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylinositol-4,5-bisphosphate + H2O
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Homo sapiens phosphatidylinositol-5-phosphate + phosphate
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?

Synonyms

Synonyms Comment Organism
type I 4-phosphatase
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Homo sapiens
type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase
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Homo sapiens
type II 4-phosphatase
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Homo sapiens