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Literature summary for 3.1.3.78 extracted from

  • Mason, D.; Mallo, G.V.; Terebiznik, M.R.; Payrastre, B.; Finlay, B.B.; Brumell, J.H.; Rameh, L.; Grinstein, S.
    Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase (2007), J. Gen. Physiol., 129, 267-283.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine involvement of phosphatidylinositol 4,5-bisphosphate phosphatase in Salmonella-induced diarrhea is explored Salmonella enterica

Cloned(Commentary)

Cloned (Comment) Organism
by cloning SigD into a mammalian expression vector, it is introduced into intact epithelia cells by microinjection: wild-type SigD induces striking morphological and functional changes that are not mimicked by a phosphatase-deficient SigD mutant C462S Salmonella enterica

Protein Variants

Protein Variants Comment Organism
C462S no functional or morphological changes in epithelial cells transfected with phosphatase-deficient mutant C462S Salmonella enterica

Organism

Organism UniProt Comment Textmining
Salmonella enterica
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O
-
 Salmonella enterica 1D-myo-inositol 1,4,5,6-tetrakisphosphate + phosphate
-
 ?
D-myo-phosphatidylinositol 4,5-bisphosphate
-
 Salmonella enterica D-myo-phosphatidylinositol 5-phosphate
-
 ?
additional information evidence is provided that SigD functions as a 4’-phosphatase that dephosphorylates D-myo-phosphatidylinositol 4,5-bisphosphate to form D-myo-phosphatidylinositol 5-phosphate Salmonella enterica ?
-
 ?

Synonyms

Synonyms Comment Organism
SigD
-
 Salmonella enterica