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Lipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble poxide hydrolase

Tran, K.L.; Aronov, P.A.; Tanaka, H.; Newman, J.W.; Hammock, B.D.; Morisseau, C.; Biochemistry 44, 12179-12187 (2005)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
(9E)-12-sulfonooxy-9-octadecenoic acid
IC50 is 0.0097 mM
Homo sapiens
(9Z)-12-sulfonooxy-9-octadecenoic acid
IC50 is above 0.1 mM
Homo sapiens
10-(sulfooxy)octadecanoic acid
IC50 is 0.0059 mM
Homo sapiens
4-nitrophenyl sulfate
IC50 is above 0.1 mM
Homo sapiens
9-hydroxy-10-(sulfooxy)octadecanoic acid
IC50 is 0.0175 mM
Homo sapiens
alpha-hydroxyfarnesyl phosphonic acid
IC50 is 0.073 mM
Homo sapiens
alpha-sulfostearic acid
IC50 is 0.0096 mM
Homo sapiens
D-galactose 6-sulfate
IC50 is above 0.1 mM
Homo sapiens
dibenzyl phosphonate
IC50 is above 0.1 mM
Homo sapiens
diethyl 2,2,2-trifluoro-1-hydroxyethyl phosphonate
IC50 is above 0.1 mM
Homo sapiens
diethyl 4-methylbenzyl phosphonate
IC50 is above 0.1 mM
Homo sapiens
diethyl allyl phosphonate
IC50 is above 0.1 mM
Homo sapiens
diethyl benzoylphosphonate
IC50 is above 0.1 mM
Homo sapiens
diethyl cyclopropyl methylphosphonate
IC50 is above 0.1 mM
Homo sapiens
diethyl ethylthiomethyl phosphonate
IC50 is above 0.1 mM
Homo sapiens
diethyl trans-cinnamyl phosphonate
IC50 is above 0.1 mM
Homo sapiens
diethyl vinylphosphonate
IC50 is above 0.1 mM
Homo sapiens
dimethyl 2-oxoheptyl phosphonate
IC50 is above 0.1 mM
Homo sapiens
dioctyl phenyl phosphonate
IC50 is 0.013 mM
Homo sapiens
dodecyl phosphonic acid
IC50 is 0.040 mM
Homo sapiens
Estrone 3-sulfate
IC50 is above 0.1 mM
Homo sapiens
L-ascorbic acid 2-sulfate
IC50 is above 0.1 mM
Homo sapiens
additional information
inhibition mechanism of sulfates, sulfonates, and phosphonates
Homo sapiens
N-acetyl-D-galactosamine 4-sulfate
IC50 is above 0.1 mM
Homo sapiens
octadecan-9-yl sulfate
IC50 is 0.0047 mM
Homo sapiens
Sodium dodecyl sulfate
IC50 is 0.0052 mM
Homo sapiens
sodium dodecyl sulfonate
IC50 is 0.0037 mM
Homo sapiens
taurocholic acid
IC50 is above 0.1 mM
Homo sapiens
taurolithocholic acid 3-sulfate
IC50 is 0.005 mM
Homo sapiens
tetraisopropyl methylenediphosphonate
IC50 is above 0.1 mM
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
kinetics
Homo sapiens
0.0036
-
2'-[2-benzothiazolyl]-6'-hydroxybenzothiazole phosphate
pH 7.0, 30°C, recombinant enzyme
Homo sapiens
0.0036
-
farnesyl diphosphate
pH 7.0, 30°C, recombinant enzyme
Homo sapiens
0.0036
-
farnesyl monophosphate
pH 7.0, 30°C, recombinant enzyme
Homo sapiens
0.0036
-
geranylgeranyl diphosphate
pH 7.0, 30°C, recombinant enzyme
Homo sapiens
0.021
-
threo-9,10-phosphonooxyoctadecanoic acid
pH 7.0, 30°C, recombinant enzyme
Homo sapiens
0.21
-
4-methylumbelliferyl phosphate
pH 7.0, 30°C, recombinant enzyme
Homo sapiens
1.6
-
4-nitrophenyl phosphate
pH 7.0, 30°C, recombinant enzyme
Homo sapiens
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
dependent on
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Reaction
Reaction
Commentary
Organism
(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate
the phosphatase activity of the enzyme is located at the N-terminal part, the C-terminal part harbors the epoxide hydrolase activity of EC 3.3.2.10, both catalytic sites act independently, reaction mechanism
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(9E)-12-sulfonooxyoctadec-9-enoic acid + H2O
-
661168
Homo sapiens
(9E)-12-hydroxyoctadec-9-enoic acid + sulfate
-
-
-
?
(9Z)-12-sulfonooxyoctadec-9-enoic acid + H2O
-
661168
Homo sapiens
(9Z)-12-hydroxyoctadec-9-enoic acid + sulfate
-
-
-
?
10-sulfonooxy-octadecanoic acid + H2O
-
661168
Homo sapiens
10-hydroxyoctadecanoic acid + phosphate
-
-
-
?
2'-[2-benzothiazolyl]-6'-hydroxybenzothiazole phosphate + H2O
i.e. attophos
661168
Homo sapiens
2'-[2-benzothiazolyl]-6'-hydroxybenzothiazole + phosphate
-
-
-
?
4-methylumbelliferyl phosphate + H2O
-
661168
Homo sapiens
4-methylumbelliferone + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
-
661168
Homo sapiens
4-nitrophenol + phosphate
-
-
-
?
farnesyl diphosphate + H2O
-
661168
Homo sapiens
farnesol + phosphate
-
-
-
?
farnesyl phosphate + H2O
-
661168
Homo sapiens
farnesol + phosphate
-
-
-
?
geranyl diphosphate + H2O
-
661168
Homo sapiens
geraniol + phosphate
-
-
-
?
geranylgeranyl diphosphate + H2O
-
661168
Homo sapiens
geranylgeraniol + phosphate
-
-
-
?
threo-9,10-phosphonooxyoctadecanoic acid + H2O
-
661168
Homo sapiens
?
-
-
-
?
Subunits
Subunits
Commentary
Organism
More
the phosphatase activity of the enzyme is located at the N-terminal part, the C-terminal part harbors the epoxide hydrolase activity of EC 3.3.2.10
Homo sapiens
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
assay at
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
assay at
Homo sapiens
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
additional information
-
additional information
inhibition kinetics
Homo sapiens
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.0037
-
IC50 is 0.0037 mM
Homo sapiens
sodium dodecyl sulfonate
0.0047
-
IC50 is 0.0047 mM
Homo sapiens
octadecan-9-yl sulfate
0.005
-
IC50 is 0.005 mM
Homo sapiens
taurolithocholic acid 3-sulfate
0.0052
-
IC50 is 0.0052 mM
Homo sapiens
Sodium dodecyl sulfate
0.0059
-
IC50 is 0.0059 mM
Homo sapiens
10-(sulfooxy)octadecanoic acid
0.0096
-
IC50 is 0.0096 mM
Homo sapiens
alpha-sulfostearic acid
0.0097
-
IC50 is 0.0097 mM
Homo sapiens
(9E)-12-sulfonooxy-9-octadecenoic acid
0.013
-
IC50 is 0.013 mM
Homo sapiens
dioctyl phenyl phosphonate
0.0175
-
IC50 is 0.0175 mM
Homo sapiens
9-hydroxy-10-(sulfooxy)octadecanoic acid
0.04
-
IC50 is 0.040 mM
Homo sapiens
dodecyl phosphonic acid
0.073
-
IC50 is 0.073 mM
Homo sapiens
alpha-hydroxyfarnesyl phosphonic acid
0.1
-
IC50 is above 0.1 mM
Homo sapiens
4-nitrophenyl sulfate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
(9Z)-12-sulfonooxy-9-octadecenoic acid
0.1
-
IC50 is above 0.1 mM
Homo sapiens
D-galactose 6-sulfate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
dibenzyl phosphonate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
diethyl 2,2,2-trifluoro-1-hydroxyethyl phosphonate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
diethyl 4-methylbenzyl phosphonate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
diethyl allyl phosphonate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
diethyl benzoylphosphonate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
diethyl cyclopropyl methylphosphonate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
diethyl ethylthiomethyl phosphonate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
diethyl trans-cinnamyl phosphonate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
diethyl vinylphosphonate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
dimethyl 2-oxoheptyl phosphonate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
Estrone 3-sulfate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
L-ascorbic acid 2-sulfate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
N-acetyl-D-galactosamine 4-sulfate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
taurocholic acid
0.1
-
IC50 is above 0.1 mM
Homo sapiens
tetraisopropyl methylenediphosphonate
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.0037
-
IC50 is 0.0037 mM
Homo sapiens
sodium dodecyl sulfonate
0.0047
-
IC50 is 0.0047 mM
Homo sapiens
octadecan-9-yl sulfate
0.005
-
IC50 is 0.005 mM
Homo sapiens
taurolithocholic acid 3-sulfate
0.0052
-
IC50 is 0.0052 mM
Homo sapiens
Sodium dodecyl sulfate
0.0059
-
IC50 is 0.0059 mM
Homo sapiens
10-(sulfooxy)octadecanoic acid
0.0096
-
IC50 is 0.0096 mM
Homo sapiens
alpha-sulfostearic acid
0.0097
-
IC50 is 0.0097 mM
Homo sapiens
(9E)-12-sulfonooxy-9-octadecenoic acid
0.013
-
IC50 is 0.013 mM
Homo sapiens
dioctyl phenyl phosphonate
0.0175
-
IC50 is 0.0175 mM
Homo sapiens
9-hydroxy-10-(sulfooxy)octadecanoic acid
0.04
-
IC50 is 0.040 mM
Homo sapiens
dodecyl phosphonic acid
0.073
-
IC50 is 0.073 mM
Homo sapiens
alpha-hydroxyfarnesyl phosphonic acid
0.1
-
IC50 is above 0.1 mM
Homo sapiens
4-nitrophenyl sulfate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
(9Z)-12-sulfonooxy-9-octadecenoic acid
0.1
-
IC50 is above 0.1 mM
Homo sapiens
D-galactose 6-sulfate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
dibenzyl phosphonate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
diethyl 2,2,2-trifluoro-1-hydroxyethyl phosphonate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
diethyl 4-methylbenzyl phosphonate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
diethyl allyl phosphonate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
diethyl benzoylphosphonate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
diethyl cyclopropyl methylphosphonate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
diethyl ethylthiomethyl phosphonate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
diethyl trans-cinnamyl phosphonate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
diethyl vinylphosphonate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
dimethyl 2-oxoheptyl phosphonate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
Estrone 3-sulfate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
L-ascorbic acid 2-sulfate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
N-acetyl-D-galactosamine 4-sulfate
0.1
-
IC50 is above 0.1 mM
Homo sapiens
taurocholic acid
0.1
-
IC50 is above 0.1 mM
Homo sapiens
tetraisopropyl methylenediphosphonate
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(9E)-12-sulfonooxy-9-octadecenoic acid
IC50 is 0.0097 mM
Homo sapiens
(9Z)-12-sulfonooxy-9-octadecenoic acid
IC50 is above 0.1 mM
Homo sapiens
10-(sulfooxy)octadecanoic acid
IC50 is 0.0059 mM
Homo sapiens
4-nitrophenyl sulfate
IC50 is above 0.1 mM
Homo sapiens
9-hydroxy-10-(sulfooxy)octadecanoic acid
IC50 is 0.0175 mM
Homo sapiens
alpha-hydroxyfarnesyl phosphonic acid
IC50 is 0.073 mM
Homo sapiens
alpha-sulfostearic acid
IC50 is 0.0096 mM
Homo sapiens
D-galactose 6-sulfate
IC50 is above 0.1 mM
Homo sapiens
dibenzyl phosphonate
IC50 is above 0.1 mM
Homo sapiens
diethyl 2,2,2-trifluoro-1-hydroxyethyl phosphonate
IC50 is above 0.1 mM
Homo sapiens
diethyl 4-methylbenzyl phosphonate
IC50 is above 0.1 mM
Homo sapiens
diethyl allyl phosphonate
IC50 is above 0.1 mM
Homo sapiens
diethyl benzoylphosphonate
IC50 is above 0.1 mM
Homo sapiens
diethyl cyclopropyl methylphosphonate
IC50 is above 0.1 mM
Homo sapiens
diethyl ethylthiomethyl phosphonate
IC50 is above 0.1 mM
Homo sapiens
diethyl trans-cinnamyl phosphonate
IC50 is above 0.1 mM
Homo sapiens
diethyl vinylphosphonate
IC50 is above 0.1 mM
Homo sapiens
dimethyl 2-oxoheptyl phosphonate
IC50 is above 0.1 mM
Homo sapiens
dioctyl phenyl phosphonate
IC50 is 0.013 mM
Homo sapiens
dodecyl phosphonic acid
IC50 is 0.040 mM
Homo sapiens
Estrone 3-sulfate
IC50 is above 0.1 mM
Homo sapiens
L-ascorbic acid 2-sulfate
IC50 is above 0.1 mM
Homo sapiens
additional information
inhibition mechanism of sulfates, sulfonates, and phosphonates
Homo sapiens
N-acetyl-D-galactosamine 4-sulfate
IC50 is above 0.1 mM
Homo sapiens
octadecan-9-yl sulfate
IC50 is 0.0047 mM
Homo sapiens
Sodium dodecyl sulfate
IC50 is 0.0052 mM
Homo sapiens
sodium dodecyl sulfonate
IC50 is 0.0037 mM
Homo sapiens
taurocholic acid
IC50 is above 0.1 mM
Homo sapiens
taurolithocholic acid 3-sulfate
IC50 is 0.005 mM
Homo sapiens
tetraisopropyl methylenediphosphonate
IC50 is above 0.1 mM
Homo sapiens
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
additional information
-
additional information
inhibition kinetics
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
kinetics
Homo sapiens
0.0036
-
2'-[2-benzothiazolyl]-6'-hydroxybenzothiazole phosphate
pH 7.0, 30°C, recombinant enzyme
Homo sapiens
0.0036
-
farnesyl diphosphate
pH 7.0, 30°C, recombinant enzyme
Homo sapiens
0.0036
-
farnesyl monophosphate
pH 7.0, 30°C, recombinant enzyme
Homo sapiens
0.0036
-
geranylgeranyl diphosphate
pH 7.0, 30°C, recombinant enzyme
Homo sapiens
0.021
-
threo-9,10-phosphonooxyoctadecanoic acid
pH 7.0, 30°C, recombinant enzyme
Homo sapiens
0.21
-
4-methylumbelliferyl phosphate
pH 7.0, 30°C, recombinant enzyme
Homo sapiens
1.6
-
4-nitrophenyl phosphate
pH 7.0, 30°C, recombinant enzyme
Homo sapiens
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
dependent on
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(9E)-12-sulfonooxyoctadec-9-enoic acid + H2O
-
661168
Homo sapiens
(9E)-12-hydroxyoctadec-9-enoic acid + sulfate
-
-
-
?
(9Z)-12-sulfonooxyoctadec-9-enoic acid + H2O
-
661168
Homo sapiens
(9Z)-12-hydroxyoctadec-9-enoic acid + sulfate
-
-
-
?
10-sulfonooxy-octadecanoic acid + H2O
-
661168
Homo sapiens
10-hydroxyoctadecanoic acid + phosphate
-
-
-
?
2'-[2-benzothiazolyl]-6'-hydroxybenzothiazole phosphate + H2O
i.e. attophos
661168
Homo sapiens
2'-[2-benzothiazolyl]-6'-hydroxybenzothiazole + phosphate
-
-
-
?
4-methylumbelliferyl phosphate + H2O
-
661168
Homo sapiens
4-methylumbelliferone + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
-
661168
Homo sapiens
4-nitrophenol + phosphate
-
-
-
?
farnesyl diphosphate + H2O
-
661168
Homo sapiens
farnesol + phosphate
-
-
-
?
farnesyl phosphate + H2O
-
661168
Homo sapiens
farnesol + phosphate
-
-
-
?
geranyl diphosphate + H2O
-
661168
Homo sapiens
geraniol + phosphate
-
-
-
?
geranylgeranyl diphosphate + H2O
-
661168
Homo sapiens
geranylgeraniol + phosphate
-
-
-
?
threo-9,10-phosphonooxyoctadecanoic acid + H2O
-
661168
Homo sapiens
?
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
More
the phosphatase activity of the enzyme is located at the N-terminal part, the C-terminal part harbors the epoxide hydrolase activity of EC 3.3.2.10
Homo sapiens
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
assay at
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
assay at
Homo sapiens
Other publictions for EC 3.1.3.76
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
708017
Keserue
Hypoxia-induced pulmonary hype ...
Mus musculus
Cardiovasc. Res.
85
232-240
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
660928
Enayetallah
Effects of human soluble epoxi ...
Homo sapiens, Rattus norvegicus
Biochem. Biophys. Res. Commun.
341
254-260
2006
-
-
2
-
4
-
2
5
2
2
-
-
-
2
-
-
2
2
-
2
8
-
12
-
-
-
-
5
-
-
-
-
-
-
-
-
-
2
-
-
4
-
-
2
-
5
2
2
-
-
-
-
-
2
-
2
8
-
12
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
661168
Tran
Lipid sulfates and sulfonates ...
Homo sapiens
Biochemistry
44
12179-12187
2005
-
-
-
-
-
-
30
8
-
1
-
-
-
1
-
-
-
1
-
-
-
-
11
1
1
-
-
-
1
-
-
-
1
-
29
-
-
-
-
-
-
-
29
30
1
8
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1
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-
11
1
1
-
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1
-
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-
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-
663275
Newman
Epoxide hydrolases: their role ...
Homo sapiens
Prog. Lipid Res.
44
1-51
2005
-
-
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1
-
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1
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1
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1
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1
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3
1
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3
1
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654749
Gomez
Structure of human epoxide hyd ...
Homo sapiens
Biochemistry
43
4716-4723
2004
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1
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2
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1
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1
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660799
Srivastava
Polymorphisms in human soluble ...
Homo sapiens
Arch. Biochem. Biophys.
427
164-169
2004
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-
1
-
7
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4
1
1
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1
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1
1
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7
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1
1
1
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1
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1
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1
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7
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4
1
1
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1
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7
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1
1
1
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1
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1
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-
657156
Newman
The soluble epoxide hydrolase ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
100
1558-1563
2003
-
-
1
-
1
-
9
2
-
2
-
5
-
2
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1
1
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2
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8
1
1
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1
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1
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1
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9
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2
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2
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5
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1
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2
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8
1
1
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1
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-
663199
Cronin
The N-terminal domain of mamma ...
Homo sapiens, Mus musculus, Rattus norvegicus
Proc. Natl. Acad. Sci. USA
100
1552-1557
2003
-
-
2
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2
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4
6
3
3
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3
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3
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3
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1
5
6
3
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4
3
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6
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3
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