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Literature summary for 3.1.3.75 extracted from

  • Zweifler, L.E.; Ao, M.; Yadav, M.; Kuss, P.; Narisawa, S.; Kolli, T.N.; Wimer, H.F.; Farquharson, C.; Somerman, M.J.; Millan, J.L.; Foster, B.L.
    Role of PHOSPHO1 in periodontal development and function (2016), J. Dent. Res., 95, 742-751 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus Q8R2H9
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Source Tissue

Source Tissue Comment Organism Textmining
osteoblast expressed by active alveolar bone osteoblasts and cementoblasts during cellular cementum formation Mus musculus
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General Information

General Information Comment Organism
physiological function in Phospho1-/- mice, acellular cementum formation and mineralization are unaffected, whereas cellular cementum deposition increases despite delayed mineralization and cementoid. Phospho1-/- mice feature disturbances in alveolar bone mineralization. Parallel to other skeletal sites, deposition of mineral-regulating protein osteopontin is increased in alveolar bone in Phospho1-/- mice. Genetic ablation of Spp1, the gene encoding osteopontin, does not ameliorate dentoalveolar defects in Phospho1-/- mice Mus musculus