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Literature summary for 3.1.3.75 extracted from

  • Pandya, M.; Rosene, L.; Farquharson, C.; Millan, J.; Diekwisch, T.
    Intravesicular phosphatase PHOSPHO1 function in enamel mineralization and prism formation (2017), Front. Physiol., 8, 805 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.75

Localization

Localization Comment Organism GeneOntology No. Textmining
secretory vesicle wall of ameloblast secretory vesicles Mus musculus 99503
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Organism

Organism UniProt Comment Textmining
Mus musculus Q8R2H9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ameloblast presence in the enamel layer, ameloblast Tomes' processes, and in the walls of ameloblast secretory vesicles Mus musculus
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enamel organ
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 Mus musculus
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mandible
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 Mus musculus
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Synonyms

Synonyms Comment Organism
PHOSPHO1
-
 Mus musculus

General Information

General Information Comment Organism
physiological function Phospho1-/- mice lack sharp incisal tips, show a 25% increase in total enamel volume, and a 2fold reduction in silver grain density of von Kossa stained ground sections. Phospho1-/- mouse enamel reveals a loss of the prominent enamel prism picket fence structure, a loss of parallel crystal organization within prisms, and a 1.56fold increase in enamel prism width. Phospho1-/- mice display a significant decrease in phosphate incorporation in the enamel layer when compared to controls Mus musculus