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BRENDA support

Literature summary for 3.1.3.75 extracted from

  • Morcos, M.W.; Al-Jallad, H.; Li, J.; Farquharson, C.; Millan, J.L.; Hamdy, R.C.; Murshed, M.
    PHOSPHO1 is essential for normal bone fracture healing an animal study (2018), Bone Joint Res., 7, 397-405 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus Q8R2H9
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-

Source Tissue

Source Tissue Comment Organism Textmining

General Information

General Information Comment Organism
physiological function calli of Phospho1-/- mice display a mild reduction of bone volume and an increase in trabecular number and a decrease in trabecular thickness and separation. There is a marked increase of osteoid volume over bone volume in the Phospho1-/- callus. Phospho1-/- fractured bone is more elastic than the wild-type bone Mus musculus