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Literature summary for 3.1.3.75 extracted from

  • Bravo, Y.; Teriete, P.; Dhanya, R.P.; Dahl, R.; Lee, P.S.; Kiffer-Moreira, T.; Ganji, S.R.; Sergienko, E.; Smith, L.H.; Farquharson, C.; Millan, J.L.; Cosford, N.D.
    Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1 (2014), Bioorg. Med. Chem. Lett., 24, 4308-4311.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.75

Inhibitors

Inhibitors Comment Organism Structure
2-(([3-(3-oxo-1,2-benzothiazol-2(3H)-yl)phenyl]sulfonyl)amino)benzoic acid
-
 Homo sapiens
2-(2,3-dimethylphenyl)-6-fluoro-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-(2,5-dimethylphenyl)-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-(2,5-dimethylphenyl)-6-fluoro-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-(3-chloro-4-fluorophenyl)-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-(3-chlorophenyl)-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-(3-methylphenyl)-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-(4-fluorophenyl)-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-(4-methylphenyl)-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-phenyl-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[2-(morpholin-4-yl)-5-(morpholin-4-ylsulfonyl)phenyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[4-(dimethylamino)phenyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[4-chloro-3-(morpholin-4-ylsulfonyl)phenyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[4-methyl-3-(morpholin-4-ylsulfonyl)phenyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[5-(morpholin-4-ylsulfonyl)-2-(pyrrolidin-1-yl)phenyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
3-(3-oxo-1,2-benzothiazol-2(3H)-yl)benzoic acid
-
 Homo sapiens
5-fluoro-2-phenyl-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
6-fluoro-2-(4-fluorophenyl)-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
6-fluoro-2-(4-methoxyphenyl)-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
6-fluoro-2-phenyl-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
ethyl 4-(3-oxo-1,2-benzothiazol-2(3H)-yl)benzoate
-
 Homo sapiens
methyl 3-(3-oxo-1,2-benzothiazol-2(3H)-yl)benzoate
-
 Homo sapiens
N,N-diethyl-3-(3-oxo-1,2-benzothiazol-2(3H)-yl)benzenesulfonamide
-
 Homo sapiens
N,N-dimethyl-3-(3-oxo-1,2-benzothiazol-2(3H)-yl)benzamide
-
 Homo sapiens
N,N-dimethyl-3-(3-oxo-1,2-benzothiazol-2(3H)-yl)benzenesulfonamide
-
 Homo sapiens
N-benzyl-3-(3-oxo-1,2-benzothiazol-2(3H)-yl)benzamide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
PHOSPHO1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00014
-
 pH and temperature not specified in the publication Homo sapiens N,N-dimethyl-3-(3-oxo-1,2-benzothiazol-2(3H)-yl)benzamide
0.0005
-
 pH and temperature not specified in the publication Homo sapiens N,N-dimethyl-3-(3-oxo-1,2-benzothiazol-2(3H)-yl)benzenesulfonamide
0.00056
-
 pH and temperature not specified in the publication Homo sapiens N,N-diethyl-3-(3-oxo-1,2-benzothiazol-2(3H)-yl)benzenesulfonamide
0.00074
-
 pH and temperature not specified in the publication Homo sapiens 6-fluoro-2-phenyl-1,2-benzothiazol-3(2H)-one
0.00081
-
 pH and temperature not specified in the publication Homo sapiens 2-(([3-(3-oxo-1,2-benzothiazol-2(3H)-yl)phenyl]sulfonyl)amino)benzoic acid
0.00082
-
 pH and temperature not specified in the publication Homo sapiens methyl 3-(3-oxo-1,2-benzothiazol-2(3H)-yl)benzoate
0.00094
-
 pH and temperature not specified in the publication Homo sapiens 2-phenyl-1,2-benzothiazol-3(2H)-one
0.00094
-
 pH and temperature not specified in the publication Homo sapiens 5-fluoro-2-phenyl-1,2-benzothiazol-3(2H)-one
0.0011
-
 pH and temperature not specified in the publication Homo sapiens 3-(3-oxo-1,2-benzothiazol-2(3H)-yl)benzoic acid
0.0011
-
 pH and temperature not specified in the publication Homo sapiens 2-[4-chloro-3-(morpholin-4-ylsulfonyl)phenyl]-1,2-benzothiazol-3(2H)-one
0.0012
-
 pH and temperature not specified in the publication Homo sapiens 2-[2-(morpholin-4-yl)-5-(morpholin-4-ylsulfonyl)phenyl]-1,2-benzothiazol-3(2H)-one
0.0012
-
 pH and temperature not specified in the publication Homo sapiens ethyl 4-(3-oxo-1,2-benzothiazol-2(3H)-yl)benzoate
0.0013
-
 pH and temperature not specified in the publication Homo sapiens 2-(4-methylphenyl)-1,2-benzothiazol-3(2H)-one
0.0018
-
 pH and temperature not specified in the publication Homo sapiens 2-(3-chloro-4-fluorophenyl)-1,2-benzothiazol-3(2H)-one
0.0018
-
 pH and temperature not specified in the publication Homo sapiens 2-[4-methyl-3-(morpholin-4-ylsulfonyl)phenyl]-1,2-benzothiazol-3(2H)-one
0.0023
-
 pH and temperature not specified in the publication Homo sapiens N-benzyl-3-(3-oxo-1,2-benzothiazol-2(3H)-yl)benzamide
0.0027
-
 pH and temperature not specified in the publication Homo sapiens 2-(3-methylphenyl)-1,2-benzothiazol-3(2H)-one
0.003
-
 pH and temperature not specified in the publication Homo sapiens 2-(2,5-dimethylphenyl)-6-fluoro-1,2-benzothiazol-3(2H)-one
0.004
-
 pH and temperature not specified in the publication Homo sapiens 2-(2,5-dimethylphenyl)-1,2-benzothiazol-3(2H)-one
0.0047
-
 pH and temperature not specified in the publication Homo sapiens 2-(2,3-dimethylphenyl)-6-fluoro-1,2-benzothiazol-3(2H)-one
0.0049
-
 pH and temperature not specified in the publication Homo sapiens 2-(4-fluorophenyl)-1,2-benzothiazol-3(2H)-one
0.0052
-
 pH and temperature not specified in the publication Homo sapiens 2-(3-chlorophenyl)-1,2-benzothiazol-3(2H)-one
0.0067
-
 pH and temperature not specified in the publication Homo sapiens 6-fluoro-2-(4-methoxyphenyl)-1,2-benzothiazol-3(2H)-one
0.0075
-
 pH and temperature not specified in the publication Homo sapiens 2-[5-(morpholin-4-ylsulfonyl)-2-(pyrrolidin-1-yl)phenyl]-1,2-benzothiazol-3(2H)-one
0.01
-
 pH and temperature not specified in the publication Homo sapiens 6-fluoro-2-(4-fluorophenyl)-1,2-benzothiazol-3(2H)-one
0.011
-
 pH and temperature not specified in the publication Homo sapiens 2-[4-(dimethylamino)phenyl]-1,2-benzothiazol-3(2H)-one