Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of phospho1-R74X-null mutant, i.e. Phospho1-/-, mice by N-ethyl-N-nitrosourea mutagenesis | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8R2H9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone | - |
Mus musculus | - |
tibia | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
PHOSPHO1 | - |
Mus musculus |
phosphoethanolamine/phosphocholine phosphatase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | long bones from Phospho1-/- mice do not fracture during 3-point bending but deform plastically. With dynamic loading nanoindentation the elastic modulus and hardness of Phospho1-/- tibiae are significantly lower than wild-type tibia. Mutant mice show significantly lower mineral:matrix ratios and lower carbonate substitutions in Phospho1-/- tibia, phenotype, overview | Mus musculus |
physiological function | PHOSPHO1 is a phosphoethanolamine/phosphocholine phosphatase involved in the generation of inorganic phosphate for bone mineralization | Mus musculus |