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Literature summary for 3.1.3.75 extracted from

  • Stewart, A.J.; Schmid, R.; Blindauer, C.A.; Paisey, S.J.; Farquharson, C.
    Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily (2003), Protein Eng., 16, 889-895.
    View publication on PubMed
Search for more literature for 3.1.3.75

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
soluble
-
 Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ Mg2+-dependent, binding site of the catalytic Mg2+ Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29700
-
 x * 29700, sequence calculation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PHOSPHO1 expression is upregulated in mineralizing cells and is implicated in the generation of inorganic phosphate for matrix mineralization ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8TCT1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-cell expression of PHOSPHO1 Homo sapiens
-
brain expression of PHOSPHO1 Homo sapiens
-
cervix expression of PHOSPHO1 Homo sapiens
-
colon expression of PHOSPHO1 Homo sapiens
-
liver fetal, expression of PHOSPHO1 Homo sapiens
-
ovary expression of PHOSPHO1 Homo sapiens
-
placenta expression of PHOSPHO1 Homo sapiens
-
SAOS-2 cell osteoblast-like cells, expression of PHOSPHO1 Homo sapiens
-
skin expression of PHOSPHO1 Homo sapiens
-
spleen expression of PHOSPHO1 Homo sapiens
-
sympathetic trunk expression of PHOSPHO1 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PHOSPHO1 expression is upregulated in mineralizing cells and is implicated in the generation of inorganic phosphate for matrix mineralization Homo sapiens ?
-
 ?
additional information three-dimensional model of PHOSPHO1, Asp-43 and Asp-123 may contribute to substrate specificity Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 29700, sequence calculation Homo sapiens

Synonyms

Synonyms Comment Organism
More PHOSPHO1 is a member of the haloacid dehalogenase superfamily of magnesium-dependent hydrolases Homo sapiens