Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-ethyl-5-phenylisoxazolium-3'-sulfonate | 0.25 mM, 5 min at 22°C, 60% loss of activity, inactivates in a concentration- and time-dependent manner, which follows pseudo-first-order kinetics, pyridoxal 5-phosphate, pyridoxine 5-phosphate or phosphate protects | Homo sapiens | |
phosphate | competitive inhibitor | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | requirement | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32000 | - |
2 * 32000 | Homo sapiens |
64000 | - |
- |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyridoxal 5'-phosphate + H2O | Homo sapiens | enzyme probably plays an important role in the hydrolysis of pyridoxal 5-phosphate to pyridoxal in erythrocytes, may be important in the regulation of pyridoxal 5-phosphate concentration | pyridoxal + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate | mechanism | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | outdated packed erythrocytes | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme has phosphotransferase activity and transfers 20-25% of the phosphoryl group from either substrate to ethanol | Homo sapiens | ? | - |
? | |
pyridoxal 5'-phosphate + H2O | enzyme probably plays an important role in the hydrolysis of pyridoxal 5-phosphate to pyridoxal in erythrocytes, may be important in the regulation of pyridoxal 5-phosphate concentration | Homo sapiens | pyridoxal + phosphate | - |
? | |
pyridoxal 5'-phosphate + H2O | mechanism, a covalent phosphoenzyme intermediate is formed during catalysis, may be an acylphosphate intermediate | Homo sapiens | pyridoxal + phosphate | - |
? | |
pyridoxine 5'-phosphate + H2O | - |
Homo sapiens | pyridoxine + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 32000 | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | 8 | - |
Homo sapiens |